Markdown keeps content clean, portable, and easy to manage. It improves consistency, simplifies version control, and reduces formatting issues from rich text editors, making collaboration between technical teams and content editors easier.
Since Sitefinity is built around structured content and rich content editing, Markdown is not native. The best approach is to use Markdown where it adds value without replacing the platform's content management strengths.
If your website is primarily Markdown-driven, a Git-based CMS such as TinaCMS is usually a stronger long-term fit because Markdown is part of the core workflow rather than an added layer.